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BC 11 hydrobromide
CAS No. 443776-49-6
BC 11 hydrobromide( —— )
Catalog No. M33833 CAS No. 443776-49-6
BC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | Get Quote |
|
| 5MG | 61 | Get Quote |
|
| 10MG | 103 | Get Quote |
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| 25MG | 220 | Get Quote |
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| 50MG | 327 | Get Quote |
|
| 100MG | 473 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBC 11 hydrobromide
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NoteResearch use only, not for human use.
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Brief DescriptionBC 11 hydrobromide is a selective TMPRSS2 and urokinase (uPA) inhibitor.BC-11 induces diminished mitochondrial activity, promotes reactive oxygen species production, and promotes apoptosis, and can be used in the study of breast cancer.
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DescriptionBC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | ROS | Serine Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number443776-49-6
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Formula Weight290.97
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Molecular FormulaC8H12BBrN2O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESBr.N=C(SCC1=CC=C(C=C1)B(O)O)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371.?
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